Raymond A. Frizzell
Director, University of Pittsburgh Basic and Translational Studies of Cystic Fibrosis
Raymond A. Frizzell, PhD
is a Professor at the University of Pittsburgh Department of Cell Biology and Director of Cystic Fibrosis Research Center. Dr Frizzell's
group is interested in the mechanisms of chloride and sodium transport across absorptive and secretory epithelial cells of the lung and kidney, in the biogenesis
and quality control pathways that influence ion channel expression, and in the membrane trafficking mechanisms that govern channel density at the cell surface.
This work focuses primarily on the anion channel, CFTR, whose mutation produces the genetic disease, cystic fibrosis, and on the epithelial sodium channel, ENaC,
a determinant of airway surface liquid volume and blood pressure regulation.
Studies in this group aim at elucidating the physiological mechanisms underlying regulation of several ion channel and transporter proteins. Our approaches include
biochemical, molecular, electrophysiologic, imaging, cell biologic and transgenic techniques. Inherited mutations in ion channels are responsible for many genetic diseases,
including cystic fibrosis (CF).